Rabies future or investigational therapies

Jump to: navigation, search

Rabies Microchapters

Home

Patient Information

Overview

Historical Perspective

Pathophysiology

Causes

Differentiating Rabies from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

Diagnostic Criteria

History and Symptoms

Physical Examination

Laboratory Findings

Electrocardiogram

X-ray

Echocardiography and Ultrasound

CT

MRI

Other Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Surgery

Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

Rabies future or investigational therapies On the Web

Most recent articles

Most cited articles

Review articles

CME Programs

Powerpoint slides

Images

American Roentgen Ray Society Images of Rabies future or investigational therapies

All Images
X-rays
Echo & Ultrasound
CT Images
MRI

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Rabies future or investigational therapies

CDC on Rabies future or investigational therapies

Rabies future or investigational therapies in the news

Blogs on Rabies future or investigational therapies

Directions to Hospitals Treating Rabies

Risk calculators and risk factors for Rabies future or investigational therapies

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Future or Investigational Therapies

Induced Coma Treatment

In 2005, the case of Jeanna Giese, a girl of 15 who survived acute, unvaccinated rabies was reported, indicating the successful treatment of rabies through induction of a coma.[1] This treatment approach was based on the theory that rabies' detrimental effects were caused by temporary dysfunctions of the brain, and that the induction of a coma, by producing a temporary partial stop in brain function, would protect the brain from damage while the body built up an immune response to the virus. After thirty-one days of isolation and seventy-six days of hospitalization, she was released from the hospital, having survived rabies. Later attempts to use the same treatment have failed.

The primary care physician in this case published in the April 2007 issue of Scientific American.[2] He notes that subsequent failures of what he calls the Milwaukee protocol did not use the cocktail of drugs used during the treatment. A point he makes for future research is the relationship of the virus to depletion of biopterin in the brain.

References

  1. Willoughby RE, Tieves KS, Hoffman GM, Ghanayem NS, Amlie-Lefond CM, Schwabe MJ, Chusid MJ, Rupprecht CE (2005). "Survival after treatment of rabies with induction of coma". N. Engl. J. Med. 352 (24): 2508–14. PMID 15958806.
  2. Rodney E. Willoughby, Jr., "A Cure for Rabies?" Scientific American, V. 256, No. 4, April 2007, p. 95 (online link)

Linked-in.jpg